研究成果

Original Paper 2009

畑 直樹、岡澤敦司、森本絹世、小埜栄一郎、佐竹 炎、小林昭雄 (2009) 「レンギョウ緑枝挿しの発根に及ぼす IBA 浸漬処理,液肥施用,日長および光強度の影響」 植物環境工学 21, 15-23.

Kim, H.-J., Ono, E., Morimoto, K., Yamagaki, T., Okazawa, A., Kobayashi, A., Satake, H. (2009) “Metabolic Engineering of Lignan Biosynthesis in Forsythia Cell Culture.” Plant Cell Physiol. 50, 2200-2209. [PubMed] open access

Kawada, T.*, Aoyama, M.*, Okada, I., Sakai, T., Sekiguchi, T., Ogasawara, M., Satake, H. (2009) “A novel inhibitory gonadotropin-releasing hormone-related neuropeptide in the ascidian, Ciona intestinalis” Peptides 30, 2200-2205. [PubMed] (*, equal contributors)

Sasaki, N., Ogasawara, M., Sekiguchi, T., Kusumoto, S., Satake, H. (2009) “Toll-like receptors of the ascidian, Ciona intestinalis: prototypes with hybrid functionalities of vertebrate Toll-like receptors.” J. Biol. Chem. 284, 27336-27343. [PubMed] open access

Sekiguchi, T., Suzuki, N., Fujiwara, N., Aoyama, M., Kawada, T., Sugase, K., Murata, Y.,Sasayama, Y., Ogasawara, M., Satake, H. (2009) Calcitonin in a protochordate, Ciona intestinalis: the prototype of the vertebrate Calcitonin/Calcitonin gene related peptide family. FEBS J. 276, 4437-4447. [PubMed] open access

Okamoto, N., Yamanaka, N., Satake, H., Saegusa, H., Kataoka, H. Mizoguchi, A. (2009) “An ecdysteroid-inducible IGF-like peptide regulates adult development of the silkmoth Bombyx mori” FEBS J. 276, 1221-1232. [PubMed] open access

Matsui, T., Matsumoto, T., Ichihara, N., Sakai, T., Satake, H., Watari, Y., Takeda, M. (2009) “The pars intercerebralis as a modulator of locomotor rhythms and feeding in the American cockroach, Periplaneta americanaPhysiol. Behav. 96, 548-556. [PubMed]

Takahashi, T., Koizumi, O., Hayakawa, E., Minobe, S., Suetsugu, R., Kobayakawa, Y., Bosch, T.C.G., David, C.N., Fujisawa, T. (2009) “Further characterization of the PW peptide family that inhibits neuron differentiation in Hydra.” Dev. Genes Evol. 219, 119-129. [PubMed]

Review & Book 2009

Kawada, T., Sekiguchi, T., Kanda, A., Sugase, K., Satake, H. (2009) Evolutionary aspects of molecular forms and biological functions of oxytocin family peptides in Handbook of Oxytocin Research: Synthesis, Storage and Release, Actions, and Drug Forms. (Jastrow H. and Feuerbach D. eds.), Nova Science Publishers, Inc., Hauppauge, NY, pp.59-85. [Publisher]

Takahashi, T., Fujisawa, T. (2009) “Important roles for epithelial cell peptides in hydra development.” BioEssays 31, 610-619. [PubMed]

高橋俊雄 (2009) 「刺胞動物ヒドラにおけるトランスジェニック研究」比較内分泌学 35(132), 39-42.

Original Paper 2008

Abdel-Mottaleb, Y., Corzo, G., Martin-Eauclaire, M.F., Satake, H., Céard, B., Peigneur, S., Nambaru, P., Bougis, P.E., Possani, L.D., Tytgat, J. (2008) “A common “hot spot” confers hERG blockade activity to alpha-scorpion toxins affecting K+ channels.” Biochem Pharmacol. 76,805-815. [PubMed]

Kawada, T., Sekiguchi, T., Itoh, Y., Ogasawara, M., Satake, H. (2008) “Characterization of a novel vasopressin/oxytocin superfamily peptide and its receptor from an ascidian, Ciona intestinalis” Peptides 29, 1672-1678. [PubMed]

Yamanaka, N., Yamamoto, S., Zitnan, D., Watanabe K., Kawada, T., Satake, H., Kaneko, Y., Hiruma, K., Tanaka, Y., Shinoda, T., Kataoka, H. (2008) “Neuropeptide Receptor Transcriptome Reveals Unidentified Neuroendocrine Pathways”. PLoS One 3, e3048. [PubMed] open access

Aoyama, M. *, Kawada, T. *, Fujie, M., Hotta, K., Sakai, T., Sekiguchi, T., Oka, K., Satoh, N.,Satake, H.(2008) “A novel biological role of tachykinins as an upregulator of oocyte growth: identification of an evolutionary origin of tachykinergic functions in the ovary of the ascidian, Ciona intestinalisEndocrinology 149, 4346-4356. [PubMed] (*, equal contributors) open access

Noguchi, A., Fukui, Y., Iuchi-Okada, A., Kakutani, S., Satake, H., Iwashita, T., Nakao, M., Umezawa, T., Ono, E. (2008) “Sequential glucosylation of a furofuran lignan, (+)-sesaminol, by Sesamum indicum UGT71A9 and UGT94D1 glucosyltransferases” Plant J. 54, 415-427. [PubMed] open access

Rameo, S., Corzo, G., Vasile, A., Satake, H., Prestipino, G., Possani, L.D. (2008) “A positive charge at the N-terminal segment of Discrepin increases the blocking effect of K+ channels responsible for the IA currents in cerebellum granular cells.” Biochem. Biophys. Acta. 780, 750-755. [PubMed]

Murata, Y., Harada, E., Sugase, K., Namba, K., Horikawa, M., Ma, J.F., Yamaji, N., Ueno, D.,Nomoto, K., Iwashita, T., Kusumoto, S. (2008) “A specific transporter for iron (III)–phytosiderophore complex involved in iron acquisition by barley roots.” Pure Appl. Chem. 80,2689-2697. [Publisher] open access

Review & Book 2008

Satake, H., Sakai, T. (2008) “Recent advances and perceptions in studies of heterodimerization between G protein-coupled receptors.” Protein Pept. Lett. 15, 300-308. [PubMed]

村田佳子、岩下 孝 (2008) 大麦の鉄取り込み機構「ミネラルの科学と最新応用技術」 糸川嘉則監修, シーエムシー出版、東京 136-143.

Takahashi T, Hayakawa E, Koizumi O, Fujisawa T. (2008) Neuropeptides and their functions in Hydra. Acta Biol. Hung. 59 (suppl.), 227-235. [PubMed]

Original Paper 2007

Kanda, A., Takuwa-Kuroda, K., Aoyama, M., Satake, H. (2007) “A novel tachykinin-related peptide receptor of Octopus vulgaris: Evolutionary aspect of invertebrate tachykinin and tachykinin-related peptide.” FEBS J. 274, 2229-2239. [PubMed] open access

Namba, K., Murata, Y., Horikawa, M., Iwashita, T., Kusumoto, S. (2007) “A practical synthesis of the phytosiderophore 2′-deoxymugineic acid: A key to the mechanistic study of iron acquisition by graminaceous Plants.” Angew. Chem. Int. Ed. 46, 7060-7063. [PubMed] open access

Harada, E., Sugase, K., Namba, K., Iwashita, T., Murata, Y. (2007) “Structural element responsible for the Fe(III)-phytosiderophore specific transport by HvYS1 transporter in barley.” FEBS Lett. 581, 4298-4302. [PubMed] open access

Furukawa, J., Yamaji, N., Wang, H., Mitani, N., Murata, Y., Sato, K., Katsuhara, M., Takeda, K., Ma, J.F. (2007) “An Aluminum-activated Citrate Transporter in Barley.” Plant Cell Physiol. 48, 1081-1091. [PubMed] open access

Hayakawa, E.,* Takahashi. T.,* Nishimiya-Fujisawa, C., Fujisawa, T. (2007) “A novel neuropeptide (FRamide) family identified by a peptidomic approach in Hydra.” FEBS J. 274, 5438-5448. *Equally contributors. [PubMed] open access

Review & Book 2007

関口俊男佐竹 炎 (2007) 「カタユウレイボヤをモデルとした神経ペプチドの構造と機能の進化」33, 71-80.

Original Paper 2006

Sakai, T., Satake, H., Takeda, M. (2006) “Nutrient-induced α-Amylase and Protease activity is Regulated by Crustacean Cardioactive Peptide (CCAP) in the Cockroach Midgut.” Peptides 27, 2157-2164. [PubMed]

Ono, E., Nakai, M., Fukui, Y., Tomimori, N., Fukuchi-Mizutani, M., Saito, M., Satake, H., Tanaka,T., Katsuta, M., Umezawa, T., Tanaka, Y. (2006) “Formation of two methylenedioxy bridges by a “Sesamum CYP81Q protein yielding a furofuran lignan, (+)-sesamin.” Proc. Natl. Acad. Sci. U.S.A. 103, 10116-10121. [PubMed] open access

Yamanaka, N., Zitnan, D., Kim, Y.J., Adams, M.E., Hua, Y.J., Suzuki, Y., Suzuki, M., Suzuki, A.,Satake, H., Mizoguchi, A., Asaoka, K., Tanaka, Y., Kataoka, H. (2006) “Regulation of insect steroid hormone biosynthesis by innervating peptidergic neurons.” Proc. Natl. Acad. Sci. U.S.A. 103, 8622-8627. [PubMed] open access

Roller, L., Tanaka, S., Kimura, K., Satake, H., Tanaka, Y. (2006) “Molecular cloning of [Thr4,His7]-corazonin (Apime-corazonin) and its distribution in the central nervous system of the honey bee Apis mellifera (Hymenoptera: Apidae)” Appl. Entomol. Zool. 41, 331-338. [J-STAGE] open access

Prochnicka-Chalufour, A., Corzo, G., Satake, H., Martin-Eauclaire, M.-F., Murgia, A. R., Prestipino, G., D’Suze, G., Possaini, L.D., Delepierre, M. (2006) “Solution Structure of Discrepin, a New K+-Channel Blocking Peptide from the α-KTx15 Subfamily.” Biochemistry. 45, 1795-1804. [PubMed] open access

Kanda, A., Takahashi, T., Satake, H., Minakata, H. (2006) “Molecular and functional characterization of a novel GnRH receptor isolated from Octopus vulgaris.” Biochem. J. 395, 125-135. [PubMed]

Murata, Y., Ma, J.F., Yamaji, N., Ueno, D., Nomoto, K., Iwashita, T. (2006) “A specific transporter for iron(III)-phytosiderophore in barley roots.” Plant J. 46, 563-572. [PubMed] open access

Ma, J.F., Tamai, K., Yamaji, N., Mitani, N., Konishi, S., katsuhara, M., Ishiguro, M., Murata, Y.,Yano, M. (2006) “A silicon transporter in rice.” Nature, 440, 688-691. [PubMed] open access

Wang Z, Takahashi T, Saito Y, Nagasaki H, Kim Ly N, Nothacker H-P, Reinscheid R.K. Yang J, Chang J.K., Shichiri M, Civelli O. (2006) Salusin β is a surrogate ligand of the mas-like G protein-coupled receptor MrgA1. Eur. J. Pharmacol. 539, 145-150. [PubMed]

Review & Book 2006

Satake, H., Sakai, T. (2006) “Impact of heterodimers between G-protein-coupled receptors for peptides: new promising targets or burdensome issues in drug development?” PharmaChem. 5, 22-25. [Publisher]

Satake, H., Kawada, T. (2006) “Overview of the primary structure, tissue-distribution, and functions of tachykinins and their receptors” Curr. Drug Targets 7, 963-974. [PubMed]

Satake, H., Kawada, T. (2006) “Neuropeptides, hormones, and their receptors in ascidians – Emerging model animals” in Invertebrate Neuropeptides and Hormones: Basic Knowledge and Recent Advances (Satake, H., ed.) pp. 253-276, Transworld Research Network, Kerala, India. [Publisher]

Takahashi, T., Hayakawa, E., Koizumi, O., Fujisawa, T. (2006) “New perspectives on neuropeptides in Hydra” in Invertebrate Neuropeptides and Hormones: Basic Knowledge and Recent Advances (Satake, H., ed.) pp. 1-15, Transworld Research Network, Kerala, India. [Publisher]

佐竹 炎 (2006) 「タキキニン関連ペプチドの進化」生体の科学 57, 428-429.

Original Paper 〜2005

Hisada, M., Satake, H., Masuda, K., Aoyama, M., Murata, K., Shinada, T., Iwashita, T., Ohfune, Y.,Nakajima, T. (2005) “Molecular components and toxicity of the venom of the solitary wasp, Anoplius samariensis,” Biochem. Biophys. Res. Commun. 330, 1048-1054. [PubMed]

Kanda, A. Satake H., Kawada, T., Minakara, H. (2005) “Novel evolutionary lineages of invertebrate Oxytocin/Vasopressin superfamily peptides and their receptors in Octopus.” Biochem. J. 387, 85-91. [PubMed]

Takahashi T, Hatta M, Yum S, Gee L, Ohtani M, Fujisawa T, Bode H.R. (2005) Hym-301, a novel peptide, regulates the number of tentacles formed in hydra. Development 132 (9), 2225-2234. [PubMed] open access

Sakai, T., Satake, H., Minakata, H., Takeda, M. (2004) “Characterization of crustacean cardioactive peptide (CCAP) as a novel insect midgut factor: Isolation, localization and stimulation of α-amylase activity and gut contraction” Endocrinology. 145, 5671-5678. [PubMed] open access

Kawada, T., Kanda, A., Minakata, H., Matsushima, O., Satake, H. (2004) “Identification of a novel receptor for an invertebrate oxytocin/vasopressin superfamily peptide: molecular and functional evolution of the oxytocin/vasopressin superfamily” Biochem. J. 382, 231-237. [PubMed]

Satake, H., Villegas, E., Oshiro, N., Terada, K., Shinada, T., Corzo, G. (2004) “Rapid and efficient identification of cysteine-rich peptides by random screening of a venom gland cDNA library from the Hexathelid spider, Macrothele gigas.” Toxicon. 44, 149-156. [PubMed]

Belokoneva, O.S., Satake, H., Mal’tseva, E.L., Pal’mina, N.P., Villegas, E., Nakajima, T., Corzo, G.(2004) “Pore formation of phospholipid membranes by the action of two hemolytic arachnid peptides of different size.” Biochem. Biophys. Acta, 1664, 182-188. [PubMed] open access

Corzo, G., Gilles, N., Satake, H., Villegas, E., Dai, L., Nakajima, T., Haupt, J. (2003) “Distinct primary structures of the major peptide toxins from of the spider Macrothele Gigas that bind to sites 3 and 4 in the sodium channel.” FEBS Lett. 547, 43-50. [PubMed] open access

Satake, H., Chen. H.Y., Varki, A. (2003) “Genes modulated by expression of GD3 synthase in Chinese Hamster Ovary cells” J. Biol. Chem. 278, 7942-7948. [PubMed] open access

Sawada, K., Ukena, K., Satake, H., Iwakoshi, E., Minakata, H., Tsutsui, K. (2002) “Novel fish hypothalamic neuropeptide.” Eur. J. Biochem. 269, 6000-6008. [PubMed] open access

Kawada, T., Furukawa, Y., Shimizu, Y., Minakata, H., Nomoto, K., Satake, H. (2002) “A novel tachykinin-related peptide receptor. Sequence, genomic organization, and functional analysis.” Eur. J. Biochem. 269, 4238-4246. [PubMed] open access

Satake, H., Hisada, M., Kawada, T., Minakata, H., Ukena, K., Tsutsui, K. (2001) “Characterization of a cDNA encoding a novel avian hypothalamic neuropeptide exerting an inhibitory effect on gonadotropin release.” Biochem. J. 354, 379-385. [PubMed]

Kawada, T., Masuda, K., Satake, H., Minakata, H., Muneoka, Y., Nomoto, K. (2000) “Identification of multiple urechistachykinin peptides, gene expression, pharmacological activity, and detection using mass spectrometric analyses.” Peptides. 21, 1777-1783. [PubMed]

Satake, H., Takuwa, K., Minakata, H. (1999) “Characterization of cDNA and expression of mRNA encoding an Achatina cardioexcitatory RFamide peptide. Peptides. 20, 1295-1302. [PubMed]

Kawada, T., Satake, H., Minakata, H., Muneoka Y, Nomoto K. (1999) “Characterization of a novel cDNA sequence encoding invertebrate tachykinin-related peptides isolated from the echiuroid worm, Urechis unicinctus.” Biochem. Biophys. Res. Commun. 263, 848-852. [PubMed]

Fujino, Y., Nagahama. T., Oumi, T., Ukena. K., Morishita, F., Furukawa, Y., Matsushima, O., Ando,M., Takahama, H., Satake, H., Minakata, H., Nomoto, K. (1999) “Possible functions of oxytocin/vasopressin-superfamily peptides in annelids with special reference to reproduction and osmoregulation.” J. Exp. Zool. 284, 401-406. [PubMed]

Nagahama, T., Ukena, K., Oumi, T., Morishita, F., Furukawa, Y., Matsushima, O., Satake, H.,Takuwa, K., Kawano, T., Minakata, H., Nomoto, K. (1999) “Localization of leech excitatory peptide, a member of the GGNG peptides, in the central nervous system of a leech (Whitmania pigra) by immunohistochemistry and in situ hybridization.” Cell Tissue Res. 297, 155-162. [PubMed]

Satake, H., Yasuda-Kamatani, Y., Takuwa, K., Nomoto, K., Minakata, H., Nagahama, T., Nakabayashi, K., Matsushima, O. (1999) “Characterization of a cDNA encoding a precursor polypeptide of a D-amino acid-containing peptide, achatin-I and localized expression of the achatin-I and fulicin genes.” Eur. J. Biochem. 261, 130-136. [PubMed] open access

Satake, H., Minakata, H., Wang, X., Fujimoto, M. (1999) “Characterization of a cDNA encoding a precursor of Carassius RFamide, structurally related to a mammalian prolactin-releasing peptide.” FEBS Lett. 446, 247-250. [PubMed] open access

Satake, H., Takuwa, K., Minakata, H., Matsushima, O. (1999) “Evidence for conservation of the vasopressin/oxytocin superfamily in Annelida.” J. Biol. Chem. 274, 5605-5611. [PubMed] open access

Review & Book 〜2005

Satake, H., Kawada, T., Nomoto, K., Minakata, H. (2003) “Insight into tachykinin-related peptides, their Receptors, and invertebrate tachykinins: a review.” Zool. Sci. 20, 533-549. [PubMed]

高橋 俊雄 (2004) 「カリフォルニア大学アーバイン校」日本比較内分泌学会ニュース 115, 45-47.

Fujisawa T, Hayakawa E, Takahashi T. (2005) Systematic identification of peptide signaling molecules by combining Hydra peptide and EST projects. Peptide Science 2004: Y. Shimohigashi (Ed.) The Japanese Peptide Society. 21-24.

Patent

新規ステビオール配糖体およびその製造方法、ならびにそれを含む甘味料組成物
公開番号: WO2018/124143、2018年7月5日

新規マンデビラ属植物及びその作出方法
公開番号: WO2017/065302、2017年4月20日

「セサミン生産用植物培養細胞およびそれを用いるセサミン製造方法」
特願2014-070759、2014年3月31日出願

「植 物 の 生 長 制 御 剤 、 植 物 の 生 長 制 御 方 法 及 び そ の 利 用 」
国際出願番号:PCT/JP2012/055232、 国際出願日:2012年3月1 日

「フロフラン型リグナン 4 位グルコース転写酵素、及びそれをコードするポリヌクレオチド」
国際出願番号:PCT/JP2010058352、2011年12月11日出願

大腸菌膜タンパク質挿入因子
公開番号:WO2011/108687、2011年9月9日

「ムギネ酸類の効率的製造方法」
特許権取得:第4117009号、2008年4月25日
国内 発明者:難波康祐、村田佳子

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Award

藤川紘樹:2023.9.7
第26回日本糖質学会奨励賞

森祥子:2023.9.7
第24回日本糖質学会ポスター賞

佐竹炎:2021.11.13
日本比較内分泌学会 小林賞

白石慧、佐竹炎:2019.9.11
第 8 回生命医薬情報学連合大会・ポスター賞

藤川紘樹:2019.8.19
第21回日本糖質学会ポスター賞

白石慧、奥田利美、宮坂奈津子、大杉知裕、佐竹炎:2018.9.21
第 7 回生命医薬情報学連合 大会・優秀ポスター発表賞

松原伸:2017.11.18
第42回日本比較内分泌学会奈良大会・若手研究者最優秀発表賞

藤川紘樹:2017.6.9
新規素材探索研究会奨励賞

山本竜也:2016.11.30
日本分子生物学会・優秀発表賞

村田佳子、本田 文、吉田雅美、渡辺健宏、難波康祐、佐治英郎、木村寛之:2016.7.31
日本微量元素学会学術集会・優秀演題賞

寺 正行:2015.9.24
Outstanding Oral Presentation Award, The 42nd International Symposium on Nucleic Acids Chemistry

高橋俊雄:2014.8.30
4th International Symposium on Non-neuronal Acetylcholine・Best Short Oral Presentation Award

山垣 亮、渡辺健宏:2014.5.15
2014年度日本質量分析学会論文賞

島本啓子:2014.3.28
日本化学会第 31 回学術賞

小村 啓:2013.12.6
ガスクロマトグラフィー研究功績賞

谷中冴子:2013.11.13
第 52 回 NMR 討論会若手ポスター賞 Ⅰ

谷中冴子:2013.6.12
日本蛋白質科学会若手奨励賞

小沼 剛:2012.11.9
第 51 回 NMR 討論会若手ポスター賞

高橋俊雄:2010.7.18
日本比較生理生化学会・吉田奨励賞

青山雅人:2009.10.22
日本比較内分泌学会・最優秀発表賞

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