Kawada T., Aoyama M., Yasuda K., Satake H.* “Cathepsin D mediates tachykinin-Induced secondary follicle growth independent of the hypothalamic–pituitary–gonadal axis in mice.” Front Endocrinol 16, 1621348 (2025). [DOI] (open access)

Osawa T., Nomura K., Shimamoto K., Fujikawa K.* “Synthesis of a fluorescent analog for exploring the functions of the bacterial glycopyrophospholipid MPIase.” Carbohydr Res 553, 109483 (2025). [DOI] (open access)

Takahashi T.*, Takase Y., Shiraishi A., Matsubara S., Watanabe T., Kirimoto S., Yamagaki T., Osawa M. “Weight Gain with advancing age is controlled by the muscarinic acetylcholine receptor M4 in male mice.” Endocrinology 166, bqaf064 (2025). [DOI] (open access)

Nomura K.*, Tsuji A., Yamashita H., Abe M., Fujikawa K., Mori S., Osawa T., Toyonaga H., Osugi T., Yasuhara K., Morigaki K., Nishiyama K., Shimamoto K.* “Membrane tubulation induced by a bacterial glycolipid.” Sci. Rep. 15, 9699 (2025). [DOI] (open access) 

Kawada T., Aoyama M., Matsubara S., Osugi T., Sakai T., Kirimoto S., Nakaoka S., Sugiura Y., Yasuda K., Satake H.* “Ovarian tachykinin signaling system induces the growth of secondary follicles during the gonadotropin-independent process.” J Biol Chem. 301, 108375 (2025). [DOI] (open access)

Yamagaki T.*, Osugi T., Shinmyo Y., Kawasaki H., Satake H. “Quantitative Analysis of Neuropeptide Y (NPY) and C-Terminal Glycine-Extended NPY by Mass Spectrometry and Their Localization in the Developing and Sexual Adult Mouse Brains.” ACS Chem. Neurosci. 16, 588–594 (2025). [DOI] (open access) 

Une R., Uegaki R., Maega S., Ono M., Bito T., Iwasaki T., Shiraishi A., Satake H., Kawano T. “FRPR-1, a G protein-coupled receptor (GPCR) in the FMRFamide-related peptide receptor family, modulates larval development as a receptor candidate of the FMRFamide-like peptide FLP-1 in Caenorhabditis elegans.” Biosci Biotechnol Biochem. 89, 586–593 (2025). [DOI]

Yamagaki T.*, Nobuhara M. “Structural Categorization of Adenine, Guanine, and Xanthine Derivatives Using Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry with 5-Nitrosalicylic Acid and 1,5-Diaminonaphtalene.” J. Am. Soc. Mass Spectrom. 36, 329–339 (2025). [DOI] (open access) 

Shiraishi A.*, Wada A., Satake H. “Evolutionary scenarios for the specific recognition of nonhomologous endogenous peptides by G protein-coupled receptor paralogs.” J Biol Chem. 301, 108125 (2025). [DOI] (open access) 

野村 薫
「大腸菌内在性糖脂質MPIaseによりサポートされる蛋白質の膜挿入機構」
月刊細胞4月号　特集「NMRによる動的構造創薬の研究」 44–47 (2025). [Info]

Takahashi T., Takase Y. “The intestinal stem cell niche: generation and utilization of intestinal organoids.” Organoids 4, 6 (2025). [DOI] (open access) 

村田 純
「植物ー微生物相互作用における揮発性低分子化合物の働き」
植物の多次元コミュニケーションダイナミクス (NTS) 214–221. (2025) [Info]

Ntoruru J. M., Osawa T., Ohnishi T., Matsui K. “Identification of linalool disaccharide glycoside (linalyl β-vicianoside) in soybean leaves and its implication for herbivore resistance.” Biosci. Biotechnol. Biochem. 89, 33–40 (2024). [DOI]

Yamada Y., Tamagaki E., Shitan N., Sato F. “Integrated metabolite profiling and transcriptome analysis reveal candidate genes involved in the biosynthesis of benzylisoquinoline alkaloids in Corydalis solida.” Plant Biotechnology 41, 267–276 (2024). [DOI] (open access)

Fodor I.*, Matsubara S.*, Osugi T., Shiraishi A., Kawada T., Satake H.*, Pirger Z.* “Lack of membrane sex steroid receptors for mediating rapid endocrine responses in molluscan nervous systems.” Front. Endocrinol. (Lausanne) 15, 1458422 (2024). [DOI] *, equally contributed (open access)

Fodor I.*, Osugi T.*, Matsubara S., Shiraishi A., Kawada T., Pirger Z.*, Satake H.* “Characterization of corazonin signaling in a molluscan model species, Lymnaea stagnalis.” Gen. Comp. Endocrinol. 357, 114594 (2024). [DOI] *, equally contributed (open access)

Kayano K, Tsutsumi T, Murata Y, Ogasa C, Watanabe T, Sato R, Karanjit S, Namba K. “Epoxide Ring-Opening Reactions for Abundant Production of Mugineic Acids and Nicotianamine Probes.” Angew Chem Int Ed Engl. 63, e202401411 (2024). [DOI] 

Taniguchi S., Nakayama S., Iguchi R., Sasakura Y., Satake H., Wada S., Suzuki N., Ogasawara M., Sekiguchi T. “Distribution of cionin, a cholecystokinin/gastrin family peptide, and its receptor in the central nervous system of Ciona intestinalis type A.” Sci Rep. 14, 6277 (2024). [DOI] (open access)

Mizuno T., Mori S., Sugahara K., Yukawa T. Koi S., Iwashina T. “Floral pigments and their perception by avian pollinators in three Chilean Puya species.” J Plant Res 137, 395–409 (2024). [DOI] 

Matsubara S., Iguchi R., Ogasawara M., Nakamura H., Kataoka T.R., Shiraishi A., Osugi T., Kawada T., Satake H. “A Novel Hemocyte-Derived Peptide and Its Possible Roles in Immune Response of Ciona intestinalis Type A.” Int. J. Mol. Sci. 25, 1979 (2024). [DOI] (open access)

Nishino H., Kanda N., Zhang B. T., Kamio M., Uchida H., Sugahara K., Nagai H., Satake M. “Okeanic acid-A, a trihydroxy fatty acid from the Okinawan cyanobacterium Okeania hirsuta.” Nat Prod Res 1–8 (2024). [DOI]

Kariya M., Omoto K., Nomura K., Yonezawa K., Kamikubo H., Nishino T., Inoie T., Rapenne G., Yasuhara K. “Lipid cubic phase with an organic-inorganic hybrid structure formed by organoalkoxysilane lipid.” Chem. Commun. 60, 2168–2171 (2024). [DOI]

Sato J., Satoh Y., Yamamoto T., Watanabe T., Matsubara S., Satake H., Kimura AP. “PTBP2 binds to a testis-specific long noncoding RNA, Tesra, and activates transcription of the Prss42/Tessp-2 gene.” Gene 893, 147907 (2024). [DOI]

Satake H., Shiraishi A., Kawada T. “Distribution of substance P receptors in mammals” in: Substance P: From Pain to Cancer (Robert Vink ed.), Elsevier, pp. 15–22 (2024). [Info]

Kayano K., Suzuki M., Murata Y., Ogae C., Namba K. “Mugineic Acids: Natural Product Chemistry Contributing to Environmental Issues.” J. Synth. Org. Chem., Jpn. 82, 1071–1078 (2024). [DOI] (open access)

高橋 俊雄、高瀬 悠太
「腸上皮オルガノイドを用いた非神経性アセチルコリンによる幹細胞制御メカニズムの解明（第2編第1章第1節）」
オルガノイド研究 ～培養・作製、活用、臨床応用～ (NTS) 193–198. (2024) [Info]

Shimamoto K., Fujikawa K., Osawa T., Mori S., Nomura K., Nishiyama K. “Key contributions of a glycolipid to membrane protein integration.” Proc. Jpn. Acad., Ser. B 100, 387–413 (2024). [DOI] (open access)

Fujikawa K. “Elucidation of Glycan Functions Based on Precise Synthesis.” Trends Glycosci. Glycotechnol. 36, E46–E50 [DOI]; J47–J51 [DOI] (2024).

Mori S., Shionyu M., Shimamoto K., Nomura K. “Bacterial Glycolipid Acting on Protein Transport Across Membranes.” ChemBioChem 25, e202300808 (2024). [DOI] (open access)

Osawa T., Fujikawa K., Shimamoto K. “Structures, functions, and syntheses of glycero-glycophospholipids.” Front. Chem. 12, 1353688 (2024). [DOI] (open access)

Nomura K., Mori S., Shimamoto K. “Roles of a Glycolipid MPIase in Sec-Independent Membrane Protein Insertion.” Membranes 14, 48 (2024). [DOI] (open access)

Koyama T. “Regulatory mechanisms of transcription factors in plant morphology and function 2.0.” Int. J. Mol. Sci. 25, 2010 (2024). [DOI] (open access)

Takase Y., Takahashi T. “Method for two-dimensional epithelial monolayer formation from mouse three-dimensional small intestinal organoids.” Methods Mol. Biol. 2749, 73–84 (2024). [DOI]

Satake H., Sasakura Y. “The neuroendocrine system of Ciona intestinalis Type A, a deuterostome invertebrate and the closest relative of vertebrates.” Mol Cell Endocrinol. 582, 112122 (2024). [DOI] (open access)

Satake H., Kawada T., Osugi T., Sakai T., Shiraishi A., Yamamoto T., Matsubara S. “Ovarian Follicle Development in Ascidians.” Zoolog Sci. 41, 60–67 (2024). [DOI] (open access)

Murata Y., Fujisawa M., Watanabe T., Kimura H., Namba K. “Effect of nicotianamine, a plant-derived chelating compound, on recovery of iron deficient mice.” Metallomics Research 3, Supple 1, 13 (2023). [DOI] (open access)

Kobayashi K., Yamamura M., Mikami B., Shiraishi A., Kumatani M., Satake H., Ono E., Umezawa T. “Anthriscus sylvestris Deoxypodophyllotoxin Synthase Involved in the Podophyllotoxin Biosynthesis.” Plant Cell Physiol. 64, 1436–1448 (2023). [DOI]

Sakai T., Yamamoto T., Watanabe T., Hozumi A., Shiraishi A., Osugi T., Matsubara S., Kawada T., Sasakura Y., Takahashi T., Satake H. “Characterization of a novel species-specific 51-amino acid peptide, PEP51, as a caspase-3/7 activator in ovarian follicles of the ascidian, Ciona intestinalis Type A.” Front. Endocrinol. 14, 1260600 (2023). [DOI] (open access)

Hanafusa Y., Shiraishi A., Hattori F. “Machine learning discriminates P2X7-mediated intracellular calcium sparks in human-induced pluripotent stem cell-derived neural stem cells.” Sci. Rep. 13, 12673 (2023). [DOI] (open access)

Fukui K., Yamamoto T., Murakawa T., Baba S., Kumasaka T., Yano T. “Catalytic mechanism of the zinc-dependent MutL endonuclease reaction.” Life Sci Alliance 6, e202302001 (2023). [DOI]

Watanabe T., Fujikawa K., Urai S., Iwaki K., Hirai T., Miyagawa K., Uratani H., Yamagaki T., Nagao K., Yokoo Y., Shimamoto K. “Identification, Chemical Synthesis, and Sweetness Evaluation of Rhamnose or Xylose Containing Steviol Glycosides of Stevia (Stevia rebaudiana) Leaves.” J. Agric. Food Chem. 71, 11158–11169 (2023). [DOI] (open access)

Tajiri M., Imai S., Konuma T., Shimamoto K., Shimada I., Akashi S. “Evaluation of Drug Responses to Human β₂AR Using Native Mass Spectrometry.” ACS Omega 8, 24544–24551 (2023). [DOI] (open access)

Yoshinaga M., Sato F., Kitagawa K., Yokota N., Sasaki S., Takeuchi M., Tsugawa H., Sugahara K., Mori S., Tera M. “Mechanism of rate controllability of water-soluble bifunctional cyclooctadiynes through cation-anion interactions.” Chem. Commun. 59, 6678–6681 (2023). [DOI]

Takase Y., Fujishima K., Takahashi T. “The 3D Culturing of Organoids from Murine Intestinal Crypts and a Single Stem Cell for Organoid Research.” J. Vis. Exp. 194, e65219 (2023). [DOI] (open access) 

Fujikawa K., Han Y., Osawa T., Mori S., Nomura K., Muramoto M., Nishiyama K., Shimamoto K. “Structural Requirements of a Glycolipid MPIase for Membrane Protein Integration.” Chem. Eur. J. 29, e202300437 (2023). [DOI] (open access)

Kaneshima T., Nojima S., Mori S., Myoda T., Nakahara K., Matsuo Y. “Isolation and identification of progenitors, glycoconjugates of β-damascenone precursors, in sweet potato (Ipomoea batatas).” Flavour Fragr J. 38, 152–162 (2023). [DOI]

Sugimoto K., Ono E., Inaba T., Tsukahara T., Matsui K., Horikawa M., Toyonaga H., Fujikawa K., Osawa T., Homma S., Kiriiwa Y., Ohmura I., Miyagawa A., Yamamura H., Fujii M., Ozawa R., Watanabe B., Miura K., Ezura H., Ohnishi T., Takabayashi J. “Identification of a tomato UDP-arabinosyltransferase for airborne volatile reception.” Nat Commun 14, 677 (2023). [DOI] (open access)

Yamamura M., Kumatani M., Shiraishi A., Matsuura Y., Kobayashi K., Suzuki A., Kawamura A., Satake H., Ragamustari S.K., Suzuki S., Suzuki H., Shibata D., Kawai S., Ono E., Umezawa T. “Two O-Methyltransferases from Phylogenetically Unrelated Cow Parsley (Anthriscus sylvestris) and Hinoki-Asunaro (Thujopsis dolabrata var. hondae) as a Signature of Lineage-Specific Evolution in Lignan Biosynthesis.” Plant Cell Physiol. 64, 124–147 (2023). [DOI]

高瀬 悠太 「美しい血管パターンが生まれるしくみ: トリ胚から迫る血管ネットワーク形成機構」 遺伝: 生物の科学 77 (4), 275–281 (2023). [Info]

Ono E., Murata J. “Exploring the Evolvability of Plant Specialized Metabolism: Uniqueness Out of Uniformity and Uniqueness Behind Uniformity.” Plant Cell Physiol. 64, 1449–1465 (2023). [DOI] (open access)

高橋 俊雄 「腸幹細胞の幹細胞性を支えるアセチルコリンシグナリング」 Medical Science Digest 49(5), 42–45 (2023). [Publisher]

Koyama T. “Regulatory mechanisms of transcription factors in plant morphology and function.” Int. J. Mol. Sci. 24, 7039 (2023). [DOI] (open access) 

Satake H. “Kobayashi Award 2021: Neuropeptides, receptors, and follicle development in the ascidian, Ciona intestinalis Type A: New clues to the evolution of chordate neuropeptidergic systems from biological niches.” Gen Comp Endocrinol. 337, 114262 (2023). [DOI] (open access)

Becker A., Yamada Y., Sato F. “California poppy (Eschscholzia californica), the Papaveraceae golden girl model organism for evodevo and specialized metabolism.” Front. Plant Sci. 14, 1084358 (2023). [DOI] (open access) 

Yamagata A. Murata Y., Namba K., Terada T, Fukai F., Shirouzu M. Uptake mechanism of iron-phytosiderophore from the soil based on the structure of yellow stripe transporter. Nat. Commun. 13, 7180 (2022). [DOI] (open access) 

Murata J., Watanabe T., Komura H. “Bacterial Volatile Isovaleric Acid Triggers Growth Alteration of Arabidopsis Seedling.” Metabolites 12, 1043. (2022). [DOI] (open access) 

Yamagaki, T., Sugahara, K., Fujikawa, K., Washida, K. “Fragmentation and Ionization Efficiency of Positional and Functional Isomers of Paeoniflorin Derivatives in Matrix-assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry.” Mass Spectrom. (Tokyo) 11, A0101 (2022). [Publisher] (open access)

Mori, S., Nomura, K., Fujikawa, K., Osawa, T., Shionyu, M., Yoda, T., Shirai, T.,Tsuda, T., Yoshizawa-Kumagaye, K., Masuda, S., Nishio, H., Yoshiya, T., Suzuki, S.,Muramoto, M., Nishiyama, K., Shimamoto, K. “Intermolecular interactions between a membrane protein and a glycolipid essential for membrane protein integration.” ACS Chem. Biol. 17, 609–618 (2022). [Publisher] (open access)

Nomura, K., Mori, S., Fujikawa, K., Osawa, T., Tsuda, T., Yoshizawa-Kumagaye,K., Masuda, S., Nishio, H., Yoshiya, T., M., Yoda, T., Shionyu, M., Shirai, T., Nishiyama, K., Shimamoto, K. “Role of a bacterial glycolipid in Sec-independent membrane protein integration” Sci. Rep. 12, 12231 (2022). [Publisher] (open access)

Hayakawa E., Guzman C., Horiguchi O., Kawano C., Shiraishi A., Mohri K., Lin M.F., Nakamura R., Nakamura R., Kawai E., Komoto S., Jokura K., Shiba K., Shigenobu S., Satake H., Inaba K., Watanabe H. (2022) Mass spectrometry of short peptides reveals common features of metazoan peptidergic neurons. Nat. Ecol. Evol. 6, 1438–1448 (2022). [DOI] (open access)

Roller L., Daubnerová I., Mizoguchi A., Satake H., Tanaka Y., Stano M., Klucar L., Žitňan D. (2022) Expression analysis of peptidergic enteroendocrine cells in the silkworm Bombyx mori. Cell Tissue Res. 389, 385–407 (2022). [DOI]

Yamashiro T., Shiraishi A., Nakayama K., Satake H. (2022) Draft Genome of Tanacetum Coccineum: Genomic Comparison of Closely Related Tanacetum-Family Plants. Int J Mol Sci. 23(13), 7039. [PubMed] open access

Koyama T.,Matsumoto E., Okuda T.,Murata J.,Horikawa M., Hata N., Okazawa A., Ono E., Satake H. (2022) Transgenic Forsythia plants expressing sesame cytochrome P450 produce beneficial lignans. Sci. Rep. 12(1), 10152. [Publisher] open access

Krasovec G., Hozumi A., Yoshida T., Obita T., Hamada M., Shiraishi A., Satake H., Horie T., Mori H.,
Sasakura Y. (2022) d-Serine controls epidermal vesicle release via NMDA receptor, allowing tissue migration during the metamorphosis of the chordate Ciona. Sci.Adv. 28(10), eabn3264. [DOI] open access

Urano K., Maruyama K., Koyama T., Gonzalez N., Inzé D., Yamaguchi-Shinozaki K., Shinozaki K. (2022) CIN-like TCP13 is essential for plant growth regulation under dehydration stress. Plant Mol. Biol. 108, 257-275. doi: 10.1007/s11103-021-01238-5 [PubMed] open access

Ohmae S., Akazawa S., Takahashi T., Izumo T., Rogi T., Nakai M. (2022) Quercetin attenuates adiogenesis and fibrosis in human skeletal muscle. Biochemical. Biophysical. Res. Commun. 615, 24-30. [PubMed]

Yamashiro T., Shiraishi, A., Nakayama K., Satake H. (2022) Key amino acids for transferase activity of GDSL lipases. Int J Mol Sci. 23(23), 15141.[DOI] open access

Fujikawa K., Mori S., Nishiyama K., Shimamoto K. CHAPTER FIVE “A bacterial glycolipid essential for membrane protein integration.” Adv. Carbohydr. Chem. Biochem. 81, 95–129 (2022). [DOI]

Koyama T., Murata J., Horikawa M., Satake H. “Production of beneficial lignans in heterologous host plants. Front. Plant Sci. 13, 1026664 (2022). [DOI] (open access) 

佐竹 炎 (2022) 「すき間で見つけた石で立派な家を作ることを目指す：小林賞受賞記」 比較内分泌学 48(175), e0023

Nishikawa H., Sawasato K., Mori S., Fujikawa K., Nomura K., Shimamoto K., Nishiyama K. “Interaction between glycolipid MPIase and proteinaceous factors during protein integration into the cytoplasmic membrane of E. coli.” Front. Mol. Biosci. 2022, 9, 986602. [DOI] (open access)

Kawada T., Osugi T., Matsubara S., Sakai T., Shiraishi A., Yamamoto T., Satake H. (2022) ”Omics Studies for the Identification of Ascidian Peptides, Cognate Receptors, and Their Relevant Roles in Ovarian Follicular Development.” Front Endocrinol (Lausanne). 13, 858885. [PubMed]

Murata Y., Murata J., Namba K. (2022) ”Unraveling the new biological roles and possibleapplications of phytosiderophores in plants and mammals.” Metallomics Research 2(2).

Yamagaki, T., Kimura, Y., Yamazaki, T. “Amidation/Non-amidation Top-down Analysis of Endogenous Neuropeptide Y in Brain Tissue by Nano Flow Liquid Chromatography Orbitrap Fourier Transform Mass Spectrometry.” J. Mass Spectrom. 56, e4716 (2021). [Publisher] (open access)

Watanabe, T., Yamagaki, T., Azuma, T., Horikawa, M. “Distinguishing Between Isomeric Neoxanthin and Violaxanthin Esters in Yellow Flower Petals Using Liquid Chromatography/Photodiode Array Atmospheric Pressure Chemical Ionization Mass Spectrometry and Tandem Mass Spectrometry.” Rapid Commun. Mass Spectrom. 35, e9142 (2021). [Publisher] (open access)

Kabe, Y., Koike, I., Yamamoto, T., Hirai, M., Kanai, A., Furuhata, R., Tsugawa, H,. Harada, E., Sugase, K., Hanadate, K., Yoshikawa, N., Hayashi, H., Noda, M., Uchiyama, S., Yamazaki, H., Tanaka, H., Kobayashi, T., Handa, H., Suematsu, M. “Glycyrrhizin Derivatives Suppress Cancer Chemoresistance by Inhibiting Progesterone Receptor Membrane Component 1.” Cancers 13, 3265 (2021). [Publisher] (open access)

Mizuno, T., Sugahara, K., Tsutsumi, C., Iino, M., Noda, N., Nakayama, M., Iwashina, T. “Anthocyanin and Flavonoids from the Greenish Blue Perianth of Puya alpestris (Bromeliaceae) and its Coloration Mechanism.” Phytochemistry 181, 112581 (2021). [Publisher]

Iwashina, T., Rahayu, S., Sugahara, K., Mizuno, T.; Tsutsumi, C.; Widyatmoko,D. “Acylated pelargonidin and cyanidin 3-sambubiosides from the flowers of Aeschynanthus species and cultivars.” Phytochemistry 192, 11295 (2021). [Publisher]

Sasaki S., Kitamura J., Endo H., Shiraishi A., Ikebukuro K., Mizutani T., Tera M. (2021) Identification of G-quadruplex sequences in severe acute respiratory syndrome coronavirus 2. Translat. Regulat. Sci. 3(3): 89-92. Doi: 10.33611/trs.2021-019 open access.

Takahashi T., Shiraishi A., Murata J., Matsubara S., Nakaoka S., Kirimoto S., Osawa M. (2021) Muscarinic receptor M3 contributes to intestinal stem cell maintenance via EphB/ephrin-B signaling. Life Sci. Alliance 4(9):e202000962. Doi: 10.26508/lsa.202000962 [PubMed] open access.

Matsubara S., Osugi T., Shiraishi A., Wada A., Satake H. (2021) Comparative analysis of transcriptomic profiles among ascidians, zebrafish, and mice: Insights from tissue-specific gene expression PLoS One. 16(9):e0254308. doi: 10.1371/journal.pone.0254308. [PubMed] open access.

Osugi T., Miyasaka N., Shiraishi A., Matsubara S., Satake H. (2021) “Cionin, a vertebrate cholecystokinin/gastrin homolog, induces ovulation in the ascidian Ciona intestinalis type A.” Sci Rep. 11(1):10911. doi: 10.1038/s41598-021-90295-3. [PubMed]. open access.

Daubnerová I., Roller L., Satake H., Zhang C., Kim YJ., Žitňan D. (2021) “Identification and
function of ETH receptor networks in the silkworm Bombyx mori.” Sci Rep. 11(1), 11693. [DOI] open access.

Kawada T., Shiraishi A., Matsubara S., Hozumi A., Horie T, Sasakura Y, Satake H. (2021) Vasopressin Promoter Transgenic and Vasopressin Gene-Edited Ascidian, Ciona intestinalis Type A (Ciona robusta): Innervation, Gene Expression Profiles, and Phenotypes. Front Endocrinol (Lausanne). 12, 668564. doi: 10.3389/fendo.2021.668564. eCollection 2021. [PubMed] open access.

Fodor I., Svigruha R., Bozsó Z., Tóth GK.,Osugi T., Yamamoto T., Satake H, Pirger Z. (2021) Functional characterization and related evolutionary implications of invertebrate gonadotropin-releasing hormone/corazonin in a well-established model species. Sci Rep. 11(1), 10028.doi: 10.1038/s41598-021-89614-5. [PubMed]. open access.

Otsuka K., Matsubara S., Shiraishi A., Takei N, Satoh Y, Terao M, Takada S, Kotani T, Satake H., Kimura AP. (2021) A Testis-Specific Long Noncoding RNA, Start, Is a Regulator of Steroidogenesis in Mouse Leydig Cells. Front Endocrinol (Lausanne). 12, 665874. doi: 10.3389/fendo.2021.665874. https://pubmed.ncbi.nlm.nih.gov/33897623/ open access.

Suzuki M., Urabe A., Sasaki S., Tsugawa R., Nishio S., Mukaiyama H., Murata Y., Masuda H., Aung M.S., Mera A., Takeuchi M., Fukushima K., Kanaki M., Kobayashi K., Chiba Y., Shrestha B.B., Nakanishi H., Watanabe T., Nakayama A., Fujino H., Kobayashi T., Tanino K., Nishizawa N.K., Namba K. (2021) “Development of a mugineic acid family phytosiderophore analog as an iron fertilizer.” Nat Commun. 12(1):1558. doi: 10.1038/s41467-021-21837-6. [PubMed]. open access.

Bandara TAMK., Otsuka K., Matsubara S., Shiraishi A., Satake H., Kimura AP. (2021) “A dual enhancer-silencer element, DES-K16, in mouse spermatocyte-derived GC-2spd(ts) cells” Biochem Biophys Res Commun. 534, 1007-1012. doi: 10.1016/j.bbrc.2020.10.049. [PubMed].

Murata Y., Yoshida M., Sakamoto N., Morimoto S., Watanabe T., Namba K. (2021) “Iron uptake mediated by the plant-derived chelator nicotianamine in the small intestine.” J. Biol. Chem. 296, 100195.doi:10.1074/jbc.RA120.015861. [PubMed]. Editor’s Pick. open access.

Mita M, Osugi T., Matsubara S., Kawada T., Satake H., Katayama H. (2021) “A relaxin-like gonad-stimulating peptide identified from the starfish Astropecten scoparius.” Mol. Reprod. Dev. 88, 34-42. doi: 10.1002/mrd.23444. [PubMed] open access.

小埜 栄一郎、 村田 純、 堀川 学 「 ゴマリグナン酵素進化から学ぶ特化代謝観」 ファルマシア, 57 (8), 715-720 (2021). [Publisher]

山垣 亮、木村優佳、山崎尭嗣 「 LC-MS による高感度ペプチド定量分析の問題点と解決法：極微量ペプチド標品の吸着と検量線作成」 J. Mass Spectrom. Soc. Jpn., 69 (2), 23-29 (2021). [Publisher]

Takahashi T., Fujishima K., Kengaku M. (2021) Modeling intestinal stem cell function with organoids. Int. J. Mol. Sci. 22, 10912. [PubMed]

佐竹 炎(2021) 「ホヤから見つかったペプチドと受容体からわかったこと」 比較生理生化学 38(3), 115-123.

川田 剛士(2021) 「バソプレシン遺伝子改変ホヤの解析」 比較内分泌学 47, e0003.

Satake H., Osugi T., Shiraishi A. (2021) Impact of Machine Learning-Associated Research Strategies on the Identification of Peptide-Receptor Interactions in the Post-Omics Era. Neuroendocrinology. doi: 10.1159/000518572. Epub ahead of print. [PubMed]

Takahashi T. (2021) Multiple roles for cholinergic signaling from the perspective of stem cell function. Int J Mol Sci. 22, 666. [PubMed]

高橋 俊雄 (2021) 「非神経細胞型アセチルコリン受容体を介した腸幹細胞の維持機構の解明」BIO Clinica 36(5), 94-97. BIOLOGY TOPICS

Yamagaki, T., Yamazaki, T. “Practical Protocol for Making Calibration Curves for Direct and Sensitive Quantitative LC Orbitrap-MS of Large Neuropeptides.” Mass Spectrom., A0087 (2020). [Publisher] (open access)

Kabe, Y., Takemoto, D., Kanai, A., Hirai, M., Ono, Y., Akazawa, S., Horikawa, M., Kitagawa, Y., Handa, H., Rogi, T., Shibata, H., Suematsu, M. “Annexin A1 Accounts for an Anti-Inflammatory Binding Target of Sesamin Metabolites” NPJ Sci Food 4, 4 (2020). [Publisher] (open access)

Ono, E., Waki, T., Oikawa, D., Murata, J., Shiraishi, A., Toyonaga, H., Kato, M., Ogata, N., Takahashi, S., Yamaguchi, M. A., Horikawa, M., Nakayama, T. “Glycoside-specific glycosyltransferases catalyze regio-selective sequential glucosylations for a sesame lignan, sesaminol triglucoside” Plant J. 101, 1221-1233 (2020). [Publisher] (open access)

Matsubara S, Shiraishi A, Osugi T, Kawada T, Satake H. (2020) “Fractionation of Ovarian Follicles and in vitro Oocyte Maturation and Ovulation Assay of Ciona intestinalis Type A” Bio Protoc. 10(7), doi: 10.21769/BioProtoc.3577 [PubMed] open access

Osugi T, Sasakura Y, Satake H. (2020) “The ventral peptidergic system of the adult ascidian Ciona robusta (Ciona intestinalis Type A) Insights from a transgenic animal model” Sci Rep. 10(1), 1892, doi: 10.1038/s41598-020-58884-w [PubMed] open access.

Matsuo R, Kobayashi S, Furuta A, Osugi T, Takahashi T, Satake H, Matsuo Y. (2020) “Distribution and physiological effect of enterin neuropeptides in the olfactory centers of the terrestrial slug Limax” J Comp Physiol A 206(3), 401-418, doi: 10.1007/s00359-020-01400-2 [PubMed]

Mita M, Osugi T, Takahashi T, Watanabe T, Satake H. (2020) “Mechanism of gamete shedding in starfish: Involvement of acetylcholine in extracellular Ca²⁺-dependent contraction of gonadal walls” Gen Comp Endocrinol. 290, 113401, doi: 10.1016/j.ygcen.2020.113401. [PubMed]

Sugahara K*, Kitao K, Yamagaki T, Koyama T*. (2020) “Practical optimization of LC-MS conditions and pretreatment methods toward the sensitive quantification of auxin in plants”. Rapid Commun. Mass Spectrom. 34, e8625. [PubMed] (*, equal contributors.) open access

Morishita F, Takahashi T, Watanabe T, Uto T, Ukena K, Furumitsu M, Horiguchi T. (2020) “Identification of neuropeptides in gastropod mollusks. – Classical and brand-new approaches” – IOP Conf. Ser.: Earth and Environ. Sci. 456, 012001, doi: 10.1088/1755-1315/456/1/012001 open access

Tsugawa H, Kabe Y, Kanai A, Sugiura Y, Hida S, Taniguchi S, Takahashi T, Matsui H, Yasukawa Z, Itou H, Takubo K, Suzuki H, Honda K, Handa H, Suematsu M. (2020) Short-chain fatty acids bind to apoptosis-associated speck-like protein to activate inflammasomal complex to prevent Salmonella infection. PLoS Biol. 18(9), e3000813. [PubMed] open access

Takahashi T, Shiraishi A, Osawa M. Upregulated nicotinic ACh receptor signaling contributes to intestinal stem cell function through activation of Hippo and Notch signaling pathways. Int Immunopharmacol. 88, 106984. [PubMed]

Mita M, Matsubara S, Osugi T, Shiraishi A, Wada A, Satake H. (2020) “A novel G protein-coupled receptor for starfish gonadotropic hormone, relaxin-like gonad-stimulating peptide” PLoS One. 15(11), e0242877. doi: 10.1371/journal.pone.0242877. [PubMed]. open access.

Mayama S, Hamazaki N, Maruyama Y, Matsubara S, Kimura AP. (2020) “Transcriptional activation of the mouse Scd2 gene by interdependent enhancers and long noncoding RNAs in ovarian granulosa cells” J Reprod Dev. 66, 435-444. doi: 10.1262/jrd.2019-161. [PubMed] open access

Harada E*., Murata J*., Ono E*., Toyonaga H., Shiraishi A., Hideshima K., Yamamoto MP., Horikawa M. (+)-Sesamin-oxidizing CYP92B14 shapes specialized lignan metabolism in sesame. Plant J. 104, 1117-1128 (2020). (*, equal contributors), doi: 10.1111/tpj.14989 [PubMed] open access

Kikuchi A., Takayama H., Tsugane H., Shiba K., Chikamoto K., Yamamoto T., Matsugo S., Ishii K., Misu H., Takamura T. Plasma half-life and tissue distribution of leukocyte cell-derived chemotaxin 2
in mice. Sci Rep 10 (1), 1-11 (2020). [PubMed] open access

山垣 亮、山崎尭嗣、木村優佳 「液体クロマトグラフィー質量分析におけるキャリーオーバー問題と解決法」 J. Mass Spectrom. Soc. Jpn., 68 (6), 99-105 (2020). [Publisher]

沢里克宏 藤川紘樹 島本啓子 西山賢一 「大腸菌におけるタンパク質膜輸送に関与する糖脂質 MPIase の発現制御機構酵素様機能をもつ糖脂質 MPIase」 化学と生物, 58 (4), 223-230 (2020). [Publisher]

菅原孝太 山垣亮 緒方是嗣 山本卓志 「質量分析イメージングを用いたビオラ花弁におけるフラボノイド類の可視化」株式会社 島津製作所 Application Note 59, 1-8 (2020).

Sakai T, Yamamoto T, Matsubara S, Kawada T, Satake H. (2020) “Invertebrate Gonadotropin-Releasing Hormone Receptor Signaling and Its Relevant Biological Actions” Int J Mol Sci. 21, 8544. doi: 10.3390/ijms21228544. [PubMed]

Takahashi T, Shiraishi A. (2020) Stem cell signaling pathways in the small intestine. Int J Mol Sci. 21(6), 2032. [PubMed]

Takahashi T. Roles of nAChR and Wnt signaling in intestinal stem cell function and inflammation. Int Immunopharmacol. 81, 106260. [PubMed]

Takahashi T. (2020) Cnidarian peptide signaling molecules. In: Advances Invertebrate (Neuro) Endocrinology, (Eds. Saleuddin S., Lange A.B., Orchard I.), Apple Academic Press, USA, Chapter1, pp. 1-24.

Takahashi T.(2020) Comparative Aspects of Structure and Function of Cnidarian Neuropeptides. Front. Endocrinol. 11, 339. [PubMed]

高橋 俊雄(2020)「非神経細胞型アセチルコリン受容体を介した腸幹細胞の分化・増殖制御機構の解明」Precision Medicine 3(6), 88 –91.「研究者の最新動向」

三田 雅敏、大杉 知宏、高橋 俊雄、渡辺 健宏、佐竹 炎(2020)「ヒトデの配偶子放出のメカニズム：ヒトデの放卵・放精はアセチルコリンによる Ca2+-influx により誘起される」 比較内分泌学 146, 79-81.

Yamagaki, T., Yamazaki, T. “Troubleshooting carry-over in LC-MS analysis of biomolecules; The case of neuropeptide Y.” Mass Spectrom., S0083 (2019). [Publisher] (open access)

Sugahara, K., Kitao, K., Watanabe, T., Yamagaki, T. “Imaging mass spectrometry analysis of flavonoids in blue viola petals and their enclosure effects on violanin during color expression.” Analytical Chemistry. 91, 896-902 (2019). [Publisher] (open access)

Nomura, K., Yamaguchi, T., Mori, S., Fujikawa, K., Nishiyama, K., Shimanouchi, T., Tanimoto, Y., Morigaki, K., Shimamoto, K. “Alteration of membrane physicochemical properties by two factors for membrane protein integration” Biophys. J., 117, 99–110. (2019) [Publisher] (open access)

Tera, M., Luedtke, N. W. “Three-Component Bioorthogonal Reactions on Cellular DNA and RNA” Bioconjug. Chem., 30, 2991–2997. (2019) [Publisher]

Yamamoto, T., Yamagaki, T., Satake, H. “Development of software for deep analysis of protein dynamics as determined by MALDI mass spectrometry-based hydrogen/deuterium exchange.” Mass Spectrom., S0082 (2019). [Publisher] (open access)

Sawasato, K., Sato, R., Nishikawa, H., Iimura, N., Kamemoto, Y., Fujikawa, K.,Yamaguchi, T., Kuruma, Y., Tamura, Y., Endo, T., Ueda, T., Shimamoto, K., Nishiyama, K. “CdsA is involved in biosynthesis of glycolipid MPIase essential for membrane protein integration in vivo” Sci. Rep., 9, 1372 (2019) [Publisher] (open access)

Hoshino, A., Mizuno, T., Shimizu, K., Mori, S., Fukada-Tanaka, S., Furukawa, K., Ishiguro, K., Tanaka, Y., Iida, S. “Generation of yellow flowers of the Japanese morning glory by engineering its flavonoid biosynthetic pathway toward aurones.” Plant Cell Physiol. 60, 1871–1879 (2019). [Publisher] (open access)

Ishikawa, Y., Murai, Y., Sakata, M., Mori, S., Matsuo, S., Senuma, W., Ohnishi, K., Hikichi, Y., Kai, K. “Activation of ralfuranone/ralstonin production by plant sugars functions in the virulence of Ralstonia solanacearum.” ACS Chem. Biol. 14, 1546–1555 (2019). [Publisher]

Murakami, Y., Iwabuchi, H., Ohba, Y., Fukami, H. “Analysis of volatile compounds from Chili peppers and characterization of Habanero (Capsicum chinense) volatiles.” J. Oleo Sci. 68, 1251–1260 (2019). [PubMed] (open access)

Nomura, Y., Seki, H., Suzuki, T., Ohyama, K., Mizutani, M., Kaku, T., Tamura, K., Ono, E., Horikawa, M., Sudo, H., Hayashi, H., Saito, K., Muranaka, T. “Functional specialization of UDP-glycosyltransferase 73P12 in licorice to produce a sweet triterpenoid saponin, glycyrrhizin.” Plant J. 99, 1127-1143 (2019). [Publisher] (open access)

Ono E*, Waki T*, Oikawa D, Murata J, Shiraishi A, Toyonaga H, Kato M, Ogata N, Takahashi S,Yamaguchi MA, Horikawa M, Nakayama T. (2019) “Glycoside-specific glycosyltransferases catalyze regio-selective sequential glucosylations for a sesame lignan, sesaminol triglucoside.” Plant J. 101(5), 1221-1233. [PubMed] (*, equal contributors.) open access

Yamashiro T*, Shiraishi A*, Satake H, Nakayama K. (2019) “Draft genome of Tanacetum cinerariifolium, the natural source of mosquito coil.” Sci Rep. 9(1), 18249. [PubMed] (*, equal contributors.) open access

Matsubara S, Shiraishi A, Osugi T, Kawada T, Satake H. (2019) “The regulation of oocyte maturation and ovulation in the closest sister group of vertebrates.” eLife. 8, pii: e49062. [PubMed] open access

Aoyama M*, Shiraishi A*, Matsubara S, Horie K, Osugi T, Kawada T, Yasuda K, Satake H.(2019) “Identification of a New Theca/Interstitial Cell-Specific Gene and Its Biological Role in Growth of Mouse Ovarian Follicles at the Gonadotropin-Independent Stage.” Front Endocrinol (Lausanne). 10, 553. [PubMed] (*, equal contributors.) open access

Tera M*, Koyama T*, Murata J, Furukawa A, Mori S, Azuma T, Watanabe T, Hori K, Okazawa A,Kabe Y,Suematsu M, Satake H, Ono E, Horikawa M.(2019) “Identification of a binding protein for sesamin and characterization of its roles in plant growth.” Sci. Rep. 9(1), 8631. [PubMed] (*, equal contributors.) open access

Nagasawa K, Matsubara S, Satake H, Osada M. (2019) “Functional characterization of an invertebrate gonadotropin-releasing hormone receptor in the Yesso scallop Mizuhopecten yessoensis.” Gen. Comp. Endocrinol. 282, 113201. [PubMed]

Shiraishi A, Okuda T, Miyasaka N, Osugi T, Okuno Y, Inoue J, Satake H. (2019) “Repertoires of G protein-coupled receptors for Ciona-specific neuropeptides.” Proc. Natl. Acad. Sci. U S A. 116(16), 7847-7856. [PubMed] open access

Fujikawa, K.; Nishiyama, K. I.;Shimamoto, K.“Enzyme-like glycolipids MPIase involved in membrane protein integration of E. coli” Trends. Glycosci. Glyc., 31, E151-E158 [Publisher]; J149-J155 [Publisher] (2019).

Fujikawa, K.; Nomura, K.; Nishiyama, K. I.; Shimamoto, K. “Novel glycolipid involved in membrane protein integration: Structure and mode of action” J. Synth. Org. Chem. Jpn. 77, 1096-1105 (2019). [Publisher]

野村薫「GPI アンカー型タンパク質における脂質アンカーの役割解明」生物物理, 59(6), 295-299 (2019). [Publisher]

Nässel DR, Zandawala M, Kawada T, Satake H. (2019) “Tachykinins: Neuropeptides That Are Ancient, Diverse, Widespread and Functionally Pleiotropic.” Front Neurosci. 13, 1262. [PubMed]

Satake H, Larhammar D, Elphick MR. (2019) Editorial: “Endocrine and Neuroendocrine Systems of Invertebrate Deuterostomes.” Front Endocrinol (Lausanne). 10, 755. [PubMed]

佐竹 炎、白石 慧 (2019) 「機械学習を活用したペプチド‐受容体ペアの予測と実証」 バイオサイエンスとバイオインダストリー 55, 478－480.

佐竹 炎、白石 慧 (2019) 「そのマッチング、人工知能（AI）の力でお助けします –機械学習を駆使した新規ペプチド-受容体の高精度予測と実証」 比較内分泌学 45, 108－111.

佐竹 炎、白石 慧 (2019) 「見えないものを見抜く–機械学習を駆使した新規ペプチド受容体の高精度予測と実証」 ファルマシア 55, 924－928.

Satake H, Matsubara S, Shiraishi A, Yamamoto T, Osugi T, Sakai T, Kawada T. (2019) “Neuropeptides, Peptide Hormones, and Their Receptors of a Tunicate, Ciona intestinalis.” Results Probl Cell Differ. 68, 107-125. [PubMed]

Satake H, Matsubara S, Shiraishi A, Yamamoto T, Osugi T, Sakai T, Kawada T. (2019) “Peptide receptors and immune-related proteins expressed in the digestive system of a urochordate, Ciona intestinalis.” Cell Tissue Res. 377(3), 293-308. [PubMed]

高橋 俊雄 (2019) 「非神経性アセチルコリンによる腸幹細胞の分化・増殖、維持機構の解明」 Medical Science Digest 45(9), 41-43「Cutting Edge」

Takahashi T.(2019) “New trends and perspectives in the function of non-neuronal acetylcholine in crypt-villus organoids in mice.” Methods Mol. Biol. 1576, 145-155. [PubMed]

Takahashi T. (2019) “Organoids for Drug Discovery and Personalized Medicine.” Annu. Rev. Pharmacol. Toxicol. 59, 447-462. [PubMed]

Takahashi T. (2019) “Cnidarian peptide signaling molecules. Advances Invertebrate (Neuro)Endocrinology (Book Title), Saber saleuddin, Angela B. Lange, Ian Orchard (Editors), APPLE ACADEMIC PRESS.” In Press.

川田 剛士、佐竹 炎 (2019) 「オキシトシン/バソプレシンファミリーの起源と進化」脳神経内科 90, 261-269.

梅澤 俊明、山村 正臣、小埜 栄一郎、白石 慧、サフェンドリ・コマーラ・ラガムスタリ (2019) 「リグナン OMT に関する最新研究動向」木材学会誌 65(1), 1-12.

堀川 学、小山 知嗣、寺正行 (2019) 「植物におけるセサミン結合タンパク質の同定と機能探索」 バイオサイエンスとインダストリー（印刷中）

Fujikawa, K., Suzuki, S., Nagase, R., Ikeda, S., Mori, S., Nomura, K., Nishiyama,K., Shimamoto, K., “Syntheses and activities of the functional structures of a glycolipid essential for membrane protein integration” ACS Chem. Biol., 13, 2719–2727 (2018) [Publisher] (open access)

Mori, S., Sugahara, K., Maeda, M., Shimamoto, K., Iwashita, T., Yamagaki, T. “Truncated palytoxin analogue, palytoxin carboxylic acid, isolated as an insecticidal compound from the red alga, Chondria armata.” Tetrahedron Lett. 59, 4420–4425 (2018). [Publisher] (open access)

Tera, M., Harati Taji, Z., Luedtke, N. W. “Intercalation-enhanced “Click” Crosslinking of DNA.” Angew. Chem. Int. Ed. 57, 15405–15409 (2018). [Publisher]

Tera, M., Glasauer, S., Luedtke, N. W. “Incorporation of azide groups into DNA using membrane-permeable nucleotide triesters in vivo.” ChemBioChem 19, 1939–1943 (2018). [Publisher]

Murakami, Y., Iwabuchi, H., Horikawa, M., Mori, S., Ohba, Y., Fukami, H. “Isolation and identification of a volatile compound in Habanero pepper (Capsicum chinense).” J. Oleo Sci. 67, 1219-1225 (2018). [PubMed] (open access)

Morishima, K., Nakamura, N., Matsui, K., Tanaka, Y., Masunaga, H.,Mori, S.,Iwashita, T., Li, X., Shibayama, M. “Formation of clusters in whiskies during the maturation process.” J. Food Sci. 84, 59–64 (2019). [Publisher] (open access)

Ono, E., Murata, J., Toyonaga, H., Nakayasu, M., Mizutani, M., Yamamoto, M. P., Umezawa, T., Horikawa, M. “Formation of a methylenedioxy bridge in (+)-epipinoresinol by CYP81Q3 corroborates with diastereomeric specialization in sesame lignans.” Plant Cell Physiol. 59, 2278-2287 (2018). [Publisher] (open access)

Okitsu, N., Matsui, K., Horikawa, M., Sugahara, K., Tanaka, Y. “Identification and characterization of novel Nemophila menziesii flavone glucosyltransferases that catalyze biosynthesis of flavone 7,4′-O-diglucoside, a key component of blue metalloanthocyanins.” Plant Cell Physiol. 59, 2075-2085 (2018). [Publisher] (open access)

Satoh T, Iitsuka T, Shiraishi A, Hozumi A, Satake H, Sasakura Y. (2018) “piRNA-like small RNAs are responsible for the maternal-specific knockdown in the ascidian Ciona intestinalis Type A.” Sci Rep. 8(1), 5869. [PubMed] open access

Takahashi T, Shiraishi A, Murata J. (2018) The coordinated activities of nAChR and Wnt signaling regulate intestinal stem cell function in mice. Int. J. Mol. Sci. 19, E738. [PubMed] open access

Koyama T, Sato F. (2018) “The function of ETHYLENE RESPONSE FACTOR genes in the light-induced anthocyanin production of Arabidopsis thaliana leaves”. Plant Biotechnol. 35, 87-92. [PubMed] open access